After three months without anyone winning the top prize, a winning ticket worth an estimated $US1.22 billion ($A1.96 billion) was sold for the drawing on Friday night.
The winner matched the white balls 3, 7, 37, 49, 55 and the gold Mega Ball 6.
The estimated jackpot on Friday was the fifth-highest ever offered by Mega Millions.
The total amount of the Mega Millions jackpot would only be distributed to a winner who chooses an annuity paid over 29 years.
Nearly all grand prize winners opt to take a cash payout, which for Friday night's drawing is an estimated $US549.7 million.
Despite the game's long odds of 1 in 302.6 million, players continued to purchase tickets as the size of the grand prize grew.
Until Friday, the last time a Mega Millions player hit the top prize was September 10.
The largest-ever Mega Millions jackpot ticket worth $US1.6 billion was sold in Florida in August 2023.
Two prizes for its compatriot Powerball lottery have been larger.
Mega Millions and Powerball are sold in 45 states, as well as Washington, DC, and the US Virgin Islands.
Powerball also is sold in Puerto Rico.
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